However, CX3CR1 was not expressed at a high level in every breast cancer cell compared with the human mammary epithelial cell line MCF-10A. In terms of CX3CL1, it was significantly more expressed in normal spinal cancellous bone than in limbs. In the present study, we found that the receptor CX3CR1 was overexpressed in the spinal metastases of breast cancer than in para-tumor tissue. Our previous study demonstrated that CX3CL1 may be involved in the process of metastasis of various malignant tumors to the spine, including breast cancer, but the molecular mechanism was still unknown. File import instruction AbstractĬ-X3-C chemokine ligand 1 (CX3CL1) has been shown to be involved in the development of multiple tumors. Select the file that you have just downloaded and select import option Reference Manager (RIS). CX3CL1 involves in breast cancer metastasizing to the spine via the Src/FAK signaling pathway. Liang Y, Yi L, Liu P, Jiang L, Wang H, Hu A, Sun C, Dong J.
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